Seminars & Events

Mathematics and Computer Science Division SeminarA Bioengineering Model of Coronary Circulation
"A Bioengineering Model of Coronary Circulation"

DATE: January 26, 2007
TIME: 1:30pm
SPEAKER: Ghassan S. Kassab, Professor, Indiana University-Purdue University at Indianapolis
LOCATION: Bldg: 308, Conference Room F148, Argonne National Laboratory
HOST: Ahmed Hassanein

Description:
In a bioengineering approach to coronary blood flow analysis, one should use the branching pattern, vascular geometry and mechanical properties of the coronary vasculature, apply the basic laws of physics (conservation of mass and momentum) to write down the governing equations, specify the appropriate boundary conditions, and solve the appropriate boundary-value problems. A complete set of data on the branching pattern and vascular geometry of the pig�s coronary vasculature, from arteries to capillaries and capillaries to veins, have been obtained in our laboratory. We have also recently determined the distensibility of the coronary blood vessels. With the distensibillity of the blood vessels known, the mechanics of the blood vessel is coupled to the mechanics of blood flow to yield a pressure-flow relation for each vessel segment. Once the pressure-flow relation of all vessel segments is known, the anatomical topology of the vascular circuit is specified by the connectivity matrix. A definite connectivity of the vascular circuit is necessary so that a repeated application of the pressure-flow relation in different segments of the circuit can synthesize the longitudinal pressure and flow distributions.

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