Essential Genes on Metabolic Maps
|Title||Essential Genes on Metabolic Maps|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Gerdes, SY, Edwards, RA, Kubal, M, Fonstein, M, Stevens, RL, Osterman, AL|
|Journal||Curr Opin Biotechnol|
Within the past five years genome-scale gene essentiality data sets have been published for ten diverse bacterial species. These data are a rich source of information about cellular networks that we are only beginning to explore. The analysis of these data, very heterogeneous in nature, is a challenging task. Even the definition of \'essential genes\' in various genome-scale studies varies from genes \'absolutely required for survival\' to those \'strongly contributing to fitness\' and robust competitive growth. A comparative analysis of gene essentiality across multiple organisms based on projection of experimentally observed essential genes to functional roles in a collection of metabolic pathways and subsystems is emerging as a powerful tool of systems biology.