Argonne National Laboratory

FIGfams: Yet Another Set of Protein Families

TitleFIGfams: Yet Another Set of Protein Families
Publication TypeJournal Article
Year of Publication2009
AuthorsMeyer, F, Overbeek, RA, Rodriguez, A
JournalNucleic Acids Research
Date Published09/2009
Other NumbersANL/MCS-P1613A-0409

We present FIGfams, a new collection of over 100,000 protein families that are the product of manual curation and close strain comparison. Using the Subsystem approach the manual curation is carried
out, ensuring a previously unattained degree of throughput and consistency. FIGfams are based on over 950,000 manually annotated proteins and across many hundred Bacteria and Archaea. Associated with each FIGfam is a two-tiered, rapid, accurate decision procedure to determine family membership for new proteins. FIGfams are freely
available under an open source license. These can be downloaded at The web site for FIGfams is