Argonne National Laboratory

MG-RAST A Technical Report and Manual for Version 3.3.6

TitleMG-RAST A Technical Report and Manual for Version 3.3.6
Publication TypeReport
Year of Publication2013
AuthorsWilke, A, Glass, EM, Bischof, J, Braithwaite, D, D'Souza, M, Gerlach, W, Harrison, T, Keegan, KP, Matthews, H, Paczian, T, Tang, W, Trimble, WL, Wilkening, J, Desai, NL, Meyer, F
Document NumberANL/MCS-TM-333
Report NumberANL/MCS-TM-333

The National Institute of Healths NHGRI publishes information (see Figure 1) describing the development of computing costs and DNA sequencing cost over time. The dramatic gap between the shrinking sequencing cost and the more of less stable computing costs is a major challenge for biomedical researchers trying to use next generation DNA sequencing platforms to obtain information on microbial communities. Wilkening provide a real currency cost for the analysis of 100 gigabasepairs of DNA sequence data using BLASTX on Amazon’s EC2 service: 900,000 US Dollars. A more recent study by University of Maryland researchers allows the computation of a real currency cost for a terabase of DNA shotgun data using complete metagenome analysis pipeline at over 5 million dollars per terabase.