Argonne National Laboratory

Systematic Comparison of the Behaviors Produced by Computational Models of Epileptic Neocortex

TitleSystematic Comparison of the Behaviors Produced by Computational Models of Epileptic Neocortex
Publication TypeJournal Article
Year of Publication2010
AuthorsWarlaumont, AS, Lee, HC, Benayoun, M, Stevens, RL, Hereld, M
JournalJ. CLinical Neurophysicology
Date Published12/2010

We compare two existing models of brain dynamics in epilepsy, one detailed (i.e., realistic) and one abstract (i.e., simplified), in terms of behavioral range and match to in vitro mouse recordings. We introduce a method for comparing across computational models that may have very different forms. Method: We first extracted high-level metrics from model and in vitro output time series. A principal components analysis (PCA) was then performed over these metrics to obtain a reduced set of derived features. These features define a low-dimensional behavior space in which quantitative measures of behavioral range and degree of match to real data can be obtained. Results: The detailed and abstract models and the mouse recordings overlapped considerably in behavior space. Both the range of behaviors and similarity to mouse data were similar between the detailed and abstract models. When no high-level metrics were used and PCA was computed over raw time series, the models overlapped minimally with the mouse recordings. Conclusions: The method introduced here is suitable for comparing across different kinds of model data and across real brain recordings. It appears that, despite differences in form and computational expense, detailed and abstract models do not necessarily differ in their behaviors.