D. Sulakhe, M. D, "GNARE - A Grid-Based Server for the Analysis of User Submitted Genomes," Preprint ANL/MCS-P1330-0306, March 2006. [pdf]
GNARE (GeNome Analysis Research Environment) is a bioinformatics server that supports both automated and expert-driven (interactive) analysis of user-submitted genomes and metagenomes. These analyses include gene function prediction and development of organism-specific metabolic reconstructions from sequence data. GNARE also provides a framework for comparative and evolutionary analysis as well as annotation of genomes and metabolic networks in the context of phenotypic and taxonomic information. Results of analyses and metabolic models are visualized and extensively annotated with information from public databases. GNARE uses automated workflows and a Grid-based computational backend to perform high-throughput analysis of genomes. The use of distributed computing in GNARE allows the analysis of an average-sized prokaryotic genome in less than five hours.