Publications

N. Maltsev, E. Marland, G. X. Yu, S. Bhatnagar, and R. Lusk, "Sentra, A Database of Signal Transduction Proteins," Nucleic Acids Research, vol. 30, no. 1, 1969, pp. 349-350, .

Sentra (http://www-wit.mcs.anl.gov/sentra) is a database of signal transduction proteins with the emphasis on microbial signal transduction. The database was updated to include classes of signal transduction systems modulated by either phosphorylation or methylation reactions such as PAS proteins and serine-threonine kinases, as well as the classical two-component histidine kinases and methyl-accepting chemotaxis proteins. Currently Sentra contains signal transduction proteins from forty-five completely sequenced prokaryotic genomes as well as sequences from 264 organisms from SWISS-PROT and TrEMBL. Signal transduction proteins are annotated with information describing conserved domains, paralogous and orthologous sequences, and conserved chromosomal gene clusters. The newly developed user interface supports flexible search capabilities and extensive visualization of the data.