LANS Informal Seminar Talks Network
"Extreme Protein Homology Search"
DATE: March 6, 2007
TIME: - Description:
SPEAKER: Fred Stevens, Biosciences
LOCATION: Building 221, Room A261, Argonne National Laboratory
HOST: Sven Leyffer
Most pairs of proteins that share a common evolutionary past -- homologs -- do not exhibit statistically significant amino acid sequence identity. Therefore, the ability to generate hypotheses of function by the exclusive use of methods dependent on statistical significance is limited and restricts assignment of function by combined computational and experimental strategies.
An opportunity exists to develop and implement homology search algorithms that are based on a "forensic" analysis of genomic data, methods we have used to identify unsuspected binding sites in the cancer-associated BRCA1 and to suggest that apparent convergent evolution of structure exhibited by several beta-domain proteins may in fact be divergent evolution of function from a common ancestral protein.
Please send questions or suggestions to Debojyoti Ghosh: ghosh at mcs dot anl dot gov.